Lower Your Heart Disease Risk by 31% with LODOCO^®

How LODOCO Works

Inflammation and Cardiovascular Disease

Low-dose colchicine (LODOCO) works to reduce inflammation in a unique way that benefits the heart and blood vessels.

Colchicine is a medication that has been used for a long time, mostly to treat gout by reducing inflammation and pain. When it comes to heart disease, inflammation plays a significant role in the development and progression of atherosclerosis, which is the buildup of plaques in the arteries that can lead to heart attacks and strokes.

At low doses, colchicine works by calming the body's response to inflammation. It does this by affecting white blood cells, which play a big role in the development of artery-blocking plaques. By interfering with certain parts inside these cells, LODOCO keeps them from becoming overly active and causing inflammation. It also lowers the levels of certain inflammation-causing substances in the body and affects various cell activities that lead to the buildup of plaques in the arteries.

By damping down the inflammation in this manner, low-dose colchicine helps to reduce the risk of cardiovascular events, such as heart attacks and strokes, particularly in people who have established cardiovascular disease or are at high risk for heart disease. This anti-inflammatory effect, with a focus on the cardiovascular system, is what makes LODOCO an innovative treatment option for reducing the risk of cardiac events.

LODOCO has shown to reduce CRP levels. CRP stands for C-reactive protein and is produced by the liver in response to inflammation, so an elevated CRP level suggests that there is inflammation occurring somewhere in the body. While we know LODOCO can help prevent serious heart problems, the exact way it achieves this protection is still being studied.