Lower Your Heart Disease Risk by 31% with LODOCO^®

There are some reports that colchicine has been associated with decreased fertility in men, though this is rare and likely reversible.  

There is limited data on the use of LODOCO during pregnancy and breastfeeding, and therefore the possible benefits of taking this medication should be weighed against the possible risks and should be discussed with a healthcare provider. 

There is only one strength of LODOCO: 0.5 mg tablets.

No, you should not consume grapefruit products while taking LODOCO, as grapefruit will increase your exposure to this medication.

LODOCO has the potential to interact with a number of medications. It is very important to speak with your healthcare provider about all medications and natural health products you may be taking before you begin treatment with LODOCO.

LODOCO tablets should be taken by mouth, one time per day. 

The effectiveness and safety of LODOCO in children and adolescents has not been established, and therefore it is generally not recommended to use this medication in this population.

LODOCO is an anti-inflammatory medication and is thought to work for cardiovascular disease by decreasing inflammation in the blood vessels and improving cardiovascular outcomes.

LODOCO is used to help lower the risk of heart attack, stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease (ASCVD) or with multiple risk factors for cardiovascular disease.

If a dose of LODOCO is missed, the missed dose should be taken as you remember, unless its very close to your next scheduled dose. If the missed dose is skipped do not take a double dose.

LODOCO can cause myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, and aplastic anemia, which can be life-threatening or fatal.

Gastrointestinal symptoms are often the first sign of colchicine toxicity, so new symptoms should prompt an evaluation for toxicity. Talk with your healthcare provider right away if you experience any changes.

Use of certain medications can reduce the metabolism of LODOCO which can increase the risk of developing blood dyscrasias.

You should be monitored closely when taking colchicine if you have any degree of renal impairment and hepatic impairment for colchicine toxicity.

Remember to tell your healthcare provider about any and all medications and over-the-counter products you are taking and about all of your health conditions.

You should not take LODOCO if:

• You have a hypersensitive to this drug or any inactive ingredient of LODOCO
• You have pre-existing blood dyscrasias
• You have renal failure, defined as having a creatinine clearance less than 15 mL/minute, or if you have severe hepatic impairment
• You are taking a medication that is a strong CYP3A4 inhibitors or P-gp inhibitor (e.g. (e.g., cyclosporine or clarithromycin).

Be sure to tell your healthcare provider about all medications you are taking and if you have any health conditions.

LODOCO can cause certain serious side effects which include:

• Blood problems. LODOCO can cause low red blood cell counts, low white blood cell counts, and low platelet counts, which can be life-threatening or may lead to death.
• Muscle weakness (neuromuscular toxicity). LODOCO can cause muscle weakness and muscle problems.

Common side effects of LODOCO include:

• diarrhea
• vomiting
• stomach-area (abdominal) cramping.
• muscle pain

Fatal overdoses have been reported with colchicine in adults and children. Keep LODOCO out of the reach of children.

For females and males of reproductive potential there is a rare risk that LODOCO may transiently impair fertility.