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Simvastatin Alternative

Are you on the right cholesterol drug?

Is it time to switch to ZYPITAMAG (pitavastatin)?

Statin Metabolism Simvastatin vs Pitavastatin
Pitavastatin vs Simvastatin in Lowering Cholesterol

Key Features of ZYPITAMAG (pitavastatin)

ZYPITAMAG is a third-generation statin that is used alongside changes to diet and exercise to help lower cholesterol in adults.

  • Reduced potential for certain drug interactions compared to simvastatin
  • Provides LDL-C ("bad cholesterol") reduction comparable to simvastatin
  • Lowers LDL-C by up to 45% and increases HDL-C by up to 7%
  • Can be taken with grapefruit juice—unlike simvastatin
  • Take anytime—unlike simvastatin, which must be taken at night.

Why Choose ZYPITAMAG Over Simvastatin

ZYPITAMAG, a next-generation statin, is a proven alternative for patients looking for effective cholesterol management. Here’s why it stands out:


  • Proven Effectiveness: ZYPITAMAG has been shown to significantly lower LDL cholesterol levels by up to 45%. In studies it offers the same cholesterol lowering effect to simvastatin.
  • Well-Tolerated: ZYPITAMAG has a reduced potential for drug-drug and drug-food interactions compared to other statins like simvastatin. Even at its highest dose, ZYPITAMAG's rates of muscle pain are only 3.1%
  • More Flexibility: Take ZYPITAMAG at any time of day with or without food, while simvastatin requires nighttime dosing.
  • Accessible and Affordable: Through Marley Drug's Direct-to-Patient model - the most you will pay for ZYPITAMAG is $34.50/month. And if its covered by your insurance, it may be as low as $0/month.

We Make Accessing ZYPITAMAG Easy

We will determine the most cost-effective option for you to access ZYPITAMAG (pitavastatin) - whether its through insurance or by cash. No matter what, the most you will ever pay for ZYPITAMAG is $1.15/day - or $34.50/month.

Plus enjoy free home delivery on all orders.


Don't have a prescription? If you don't have a prescription, you can request one with this form and we'll contact your doctor for you.

Hear from our Customers

After finding the Marley Drug website and reading about Zypitamag I contacted my physician. After some research he gave me approval to use this medicine. I find Zypitamag effective as I had bloodwork done ...
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T. Thomas
The results are back after 2 months on Zypitamag. Wow! My numbers have come way down, and I am so happy with the results!
Richard H.
I just had my 3 month follow up blood work done for my cholesterol after using Zypitamag. The results were outstanding! The best lipid levels I have had in treating cholesterol... I have not had any side ...
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Garrick M
I have always had trouble with statins. My doctor recommended Marley Drug’s statin, Zypitamag (pitavastatin), and I have been taking that with no side effects and my bad cholesterol has gone down significantly ...
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Jacquie N.
This drug is a miracle for me! I have tried every statin on the market with copious amounts of muscle pain weakness, back pain overall, and aching in every joint. My family has genetic high cholesterol ...
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Nurse from Houston, TX
Zypitamag has made a world of difference in my health. I have not had any side effects of muscle pain. Thank you, Marley Drug for making the process of getting this medication so fast and easy. I never ...
Read More
Anne H.
Stock photos are used to represent actual testimonials of Marley Drug customers.

How to Get Started with ZYPITAMAG

Consult Your Doctor

Discuss your symptoms, concerns, and goals to see if ZYPITAMAG is the right fit for you.

Send Your Prescription to Marley Drug

If ZYPITAMAG is right for you, be sure to access ZYPITAMAG through Marley Drug’s Direct-to-Patient program, ensuring affordability and convenience.

We will ship it to your home

We offer free shipping to all 50 states. Our average delivery time is 2 days.

What to Consider When Choosing the Right Statin


Choosing the right statin isn’t just about lowering cholesterol—it’s about finding a medication that fits your unique health profile and lifestyle. Here are some key factors to keep in mind:


1. What Statin Intensity Do I Need?


Statin intensity refers to how much a statin can lower LDL ("bad") cholesterol levels. Statins are categorized into low, moderate, and high intensity. The right intensity for you depends on your individual cholesterol goals and medical history.


The Rule of 6

Doubling the statin dose (e.g., from simvastatin 10mg to 20mg) typically results in an additional 6% reduction in LDL-C. However, increasing the dose often comes with a higher risk of side effects, such as muscle pain or liver enzyme elevations.


This means that while doubling a statin dose can offer a slight improvement in cholesterol reduction, the trade-off may not always be worth it.


How ZYPITAMAG Compares to Simvastatin

  • Zypitamag 2mg offers similar LDL-lowering benefits to Simvastatin 20mg.
  • Zypitamag 4mg is comparable to Simvastatin 40mg in terms of reducing LDL cholesterol.

If you're not meeting your LDL-C goals with a statin alone, instead of simply increasing the dose, you might benefit from combination therapy. Adding a medication like ezetimibe, which blocks cholesterol absorption in the intestine, can provide significant additional LDL reduction without increasing statin side effects.


2. Statins and their Effect on Blood Sugar


Statins, including simvastatin, can increase blood sugar levels. Data suggests that statins like ZYPITAMAG (pitavastatin), may have less of an effect on this compared to other statins. Click to read more about the link between statins and blood sugar.


3. If You're Taking Multiple Medications


70-80% of medications, including simvastatin, are metabolized by the same enzyme family called the cytochrome 450 (CYP450) family of enzymes. Newer statins, like ZYPITAMAG, bypass these enzyme pathways and have reduced potential for drug-drug and drug-food interactions.


4. Side Effects and Tolerability


In general, higher doses of statins are associated with a greater likelihood of side effects. If you experience side effects while taking a statin, it’s important to speak with your healthcare provider. They may recommend lowering your dose or switching to a different statin to see how your body responds.


Muscle Pain: The #1 Reason People Stop Taking Statins

Muscle pain is the most commonly reported reason for discontinuing statin use. However, there is hope, as a recent study found that the majority of those who experienced statin side effects, with proper consultation from their healthcare provider, can switch doses or statins to find a statin that works for them.


This finding underscores the importance of discussing any discomfort with your doctor to determine the true cause and explore alternative options.


If you’re facing these challenges, switching to a moderate intensity statin like ZYPITAMAG (pitavastatin) may be a good option.

Have questions about statins?
Talk with a pharmacist today.

Call us for a free pharmacy consult.

800-810-7790

Common Questions About Statins